创新型标志物

可在妊娠孕期（11周之后）预测子痫前期发病风险

子痫前期临床危害巨大，易造成孕妇多器官受累，增加母婴死亡风险

子痫前期在全球范围内的发病率约占所有妊娠的2%~4%，每年大约导致46,000孕产妇和500,000胎儿或新生儿死亡。1


孕16周前服用低剂量阿司匹林

对子痫前期有较好的干预和预防作用

ASPRE多中心、随机、双盲研究表明，自孕11～14周起至孕36周，服用150 mg/d的阿司匹林可以有效降低

早产型子痫前期高危孕妇早产发生风险，干预效果明显。2


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参考文献

1. Magee LA, Nicolaides KH, Dadelszen P. Preeclampsia[J]. NEJM, 2022.

2. Rolnik DL, D Wright, Poon LC, et al. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia[J]. The New England journal of medicine, 2017.

3. American College of Obstetricians and Gynecologists. ACOG practice bulletin no.202 gestational hypertension and preeclampsia. Obstet Gynecol, 2019.

4. National Institute for Health and Care Excellence. Hypertension in pregnancy: diagnosis and management (NICE guideline NG133). 2019.

5. 中华医学会妇产科学分会妊娠期高血压疾病学组. 妊娠期高血压疾病诊治指南(2022). 中华妇产科杂志, 2022 .

6. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre‐eclampsia: A pragmatic guide for first‐trimester screening and prevention[J]. International Journal of Gynecology & Obstetrics, 2019.